Objectives: In this brief report, we compared peripheral nerve morphology in tissues
obtained from Berkeley transgenic SCD mice and control animals. Methods: Sciatic nerves
were visualized using light and transmission electron microscopy. Myelin basic protein
expression was assessed through Western blot. Blood–nerve barrier permeability was
measured using Evan's blue plasma extravasation. Results: Peripheral fibers from SCD
mice have thinner myelin sheaths than control mice and widespread myelin instability as …