Sensory system involvement in infantile spinal muscular atrophy
A Marshall, LW Duchen - Journal of the neurological sciences, 1975 - Elsevier
Nine cases of infantile spinal muscular atrophy were studied post-mortem. Their ages at
death ranged from 5 months to 10 years. In all cases severe loss of anterior horn cells in the
spinal cord and neurogenic muscular atrophy were characteristic of this disease. In 6 cases
there was also loss of myelin in the posterior columns particularly affecting the lumbar
contribution. Sensory ganglia, especially from the lumbar region, contained nodules of
Nageotte, indicating sensory neuron degeneration. These sensory abnormalities were more …
death ranged from 5 months to 10 years. In all cases severe loss of anterior horn cells in the
spinal cord and neurogenic muscular atrophy were characteristic of this disease. In 6 cases
there was also loss of myelin in the posterior columns particularly affecting the lumbar
contribution. Sensory ganglia, especially from the lumbar region, contained nodules of
Nageotte, indicating sensory neuron degeneration. These sensory abnormalities were more …
